R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners
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چکیده
منابع مشابه
Liprin- has LAR-independent functions in R7 photoreceptor axon targeting
In the Drosophila visual system, the color-sensing photoreceptors R7 and R8 project their axons to two distinct layers in the medulla. Loss of the receptor tyrosine phosphatase LAR from R7 photoreceptors causes their axons to terminate prematurely in the R8 layer. Here we identify a null mutation in the Lipringene based on a similar R7 projection defect. Liprinphysically interacts with the inac...
متن کاملCell-Autonomous and -Nonautonomous Functions of LAR in R7 Photoreceptor Axon Targeting
During Drosophila visual system development, photoreceptors R7 and R8 project axons to targets in distinct layers of the optic lobe. We show here that the LAR receptor tyrosine phosphatase is required in the eye for correct targeting of R7 axons. In LAR mutants, R7 axons initially project to their correct target layer, but then retract to the R8 target layer. This targeting defect can be fully ...
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Original approval signatures are on file with the Graduate School and the University of Oregon Libraries. The development of a functional nervous system is paramount for the ability of animals to interact with their environments. Minor defects in nervous system function compromise the effectiveness of sensing and responding to stimuli. Severe defects in nervous system function often lead to ext...
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R7 photoreceptor specification requires Notch activity
The eight photoreceptors in each ommatidium of the Drosophila eye are assembled by a process of recruitment [1,2]. First, the R8 cell is singled out, and then subsequent photoreceptors are added in pairs (R2 and R5, R3 and R4, R1 and R6) until the final R7 cell acquires a neuronal fate. R7 development requires the Sevenless receptor tyrosine kinase which is activated by a ligand from R8 [3]. He...
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ژورنال
عنوان ژورنال: eLife
سال: 2021
ISSN: 2050-084X
DOI: 10.7554/elife.65895